Retatrutide

Retatrutide -5mg, 10mg

CAS Number: 2632576-96-3
Molecular Formula: C₂₉₈H₄₇₀N₈₂O₈₃
Molecular Weight: 6937.57 g/mol
Synonyms: LY3437943; Triple Agonist (GLP-1/GIP/GCGR)

Description:

Retatrutide is a synthetic peptide engineered as a triple agonist of the glucagon-like peptide-1 (GLP-1) receptor, glucose-dependent insulinotropic polypeptide (GIP) receptor, and glucagon receptor (GCGR). This multi-pathway receptor activation is of significant interest in metabolic research for its potential to influence energy expenditure, glucose regulation, and adipose tissue metabolism.

In vitro and preclinical studies evaluate Retatrutide’s effect on appetite signaling, insulin sensitivity, hepatic fat reduction, and lipid mobilization. Its interaction with GCGR provides additional research value in models examining thermogenesis, enhanced fat oxidation, and metabolic rate modulation beyond traditional incretin pathways.

Retatrutide is widely studied in research exploring multi-receptor incretin mimetics, metabolic disease modeling, and advanced body-weight regulation mechanisms, particularly due to its robust activity across three key hormonal systems.

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